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Monitor Closely (three)pentobarbital will lessen the level or result of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Potent or moderate CYP3A4 inducers could raise charge of diazepam elimination; consequently, efficacy of diazepam could be lowered.Barbiturates can induce hepatic microsomal